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It has long been known that diabetes is a risk factor for heart failure. Analysis from the Framingham Heart Study established that men with type 2 diabetes had a 2.4-fold increase in heart failure and women had a five-fold increase. This link between the diseases is not just one way as more recent research has found the reverse to be in effect as well, that heart failure indeed is its own risk factor for diabetes mellitus.
Of all clinical trial activity in dyslipidemia, perhaps the most anticipated area is reduction of cardiovascular (CV) outcomes.
The two furthest developed PCSK9 inhibitors have had very similar clinical development timelines.
Heart failure is a chronic condition that is of major concern to the healthcare community. 5.8 million Americans and 23 million people globally are estimated to have heart failure.