Since the ASCO 2014 abstracts were released to the public on May 14, 2014 at 5:00pm EDT, the pre-meeting buzz in the press has been mostly about immunotherapies – specifically immunotherapies targeted against the immune checkpoint inhibitors Programmed (Cell) Death 1 (PD1) and its ligand (PDL1). The late-stage investigational PD1/PDL1 antagonists pembrolizumab/MK-3475 (Merck), nivolumab (Ono/Bristol-Myers Squibb) and MPDL3280A (Genentech/Roche) have garnered most of the pre-ASCO press and results of trials with several other early-stage PD1/PDL1 biologics, pidilizumab (Curetech), MEDI4736 (MedImmune/AstraZeneca), MSB-0010718C (Merck KGaA), will also be presented at ASCO.
But what other immunotherapies warrant our attention at ASCO 2014? Promising results from immunotherapies in early-stage clinical development from a diverse array of industry and academic sponsors and/or collaborations will be presented. Many of these therapies have already advanced into later-stage clinical trials or will be evaluated in additional trials within the next year (1). Highlighted below are the presentations from three types of immunotherapies.
Chimeric Antigen Receptor (CAR)-Engineered T Cells
Oncolytic Viruses
Antibody-Drug Conjugates
Presentations from phase I trials include:
Presentations from phase I/II and phase II trials include:
Summary table of the highlighted immunotherapies
| Drug Name | Disease | Target | Trial Phase at ASCO | Industry Developer | Abstract |
| CAR-Engineered T Cells | |||||
| CD19-targeted CAR+T cells | CLL | CD19 | I | Juno | 7020 |
| CTL019 | ALL, CLL | CD19 | I, II | Novartis | |
| PG13-CD19-H3 transduced PBL/KTE-C19 CAR | B cell lymphoma or leukemia | CD19 | I | Kite | 3079 |
| Oncolytic Viruses | |||||
| Cavatak/CVA-21 | melanoma | II | Viralytics | 3031 | |
| enadenotucirev | epithelial solid tumors | I | PsiOxus | 3103 | |
| pelareorep/Reolysin | brain tumors | I | Oncolytics | 3104 | |
| Antibody-Drug Conjugates | |||||
| DMOT4039A | pancreatic or ovarian cancers | MSLN | I | Genentech | 2529 |
| DNIB0600A | NSCLC or ovarian cancer | NaPi2b (SLC34A2) | I | Genentech | 2504 |
| DSTP3086S | prostate cancer | STEAP-1 | I | Genentech | 5024 |
| IMGN529 | NHL | CD37 | I | ImmunoGen | 8526 |
| IMGN853 | ovarian cancer or FRα positive solid tumors | FRα | I | ImmunoGen | 5571 |
| MLN0264 | gastrointestinal tumors | GCC | I | Millennium | 3546 |
| SGN-LIV1A | breast cancer | LIV-1 | I | Seattle Genetics | TPS1143 |
| IMMU-130 | colorectal cancer | CEACAM5 | I/II | Immunomedics | 3106 |
| IMMU-132 | solid tumors | Trop-2 | I/II | Immunomedics | 3032 |
| PSMA ADC | prostate cancer | PSMA | II | Progenics | 5023 |
So look past the frenzy about the anti-PD1 and anti-PDL1 biologics at ASCO 2014 and look at the presentations about other types of immunotherapies, namely CAR-engineered T cells, oncolytic viruses and antibody-drug conjugates. Some of these early-stage immunotherapies could steal the show at ASCO 2015
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