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Datamonitor Healthcare
Topic Comment wire
Datamonitor Healthcare
PTC Therapeutics announced the failure of its ACT CF trial of Translarna (ataluren) in nonsense mutation cystic fibrosis (nmCF) patients, bringing a halt to any further planned developmental activities in the indication. Although there was a slight treatment effect, Translarna failed to significantly improve pulmonary measures compared to placebo.
Topic Comment wire
Datamonitor Healthcare
Pfizer has suspended the global development of its pipeline proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, bococizumab, due to a lack of predicted value.
Topic Drug approval Comment wire
Datamonitor Healthcare
Data presented at ATS 2016 support the use of biologics in severe refractory eosinophilic asthma, and will inform the stringent formulary access policies expected to be implemented by payers for these high-cost therapies.
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