Pharma Intelligence is part of the Business Intelligence Division of Informa PLC
This is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC's registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.
Citeline’s completed clinical trial landscape provides a more granular view of how companies are progressing their pipelines and the disease strategies they are pursuing, compared to static pipeline snapshots.
Below, Citeline delves into 9 key tables that feature in our white paper 2017 Completed Trials: Status Quo or No?, examining the landscape of industry-sponsored clinical trials completed in 2017[1]. It covers:
Across the nine therapeutic areas (TAs) included in Trialtrove, the rank order with respect to numbers of completed trials remained unchanged between 2016 and 2017 (Table 1).
The top three TAs remain Oncology, Autoimmune/Inflammation (A/I), and CNS. In terms of absolute numbers, just over 80 more oncology trials completed in 2017 compared to 2016. The other TAs with more trials in 2017 include CNS, Cardiovascular, Vaccines, Ophthalmology, and Genitourinary.
Within each TA, Table 2 compares the top 10 diseases with completed trials in 2017 with the prior three years. The sum of trials for these diseases was highest in 2017, and apart from trials assessing efficacy in hepatitis C virus (HCV), the absolute numbers of trials for 2017 were close to, or exceeded the 2016 counts.
The diseases with 25 or more trials that attained primary outcome(s) were led by breast cancer, with a total of 58 trials, which accounted for 34.7% of all completed trials (Table 3). The top-ranked disease, multiple myeloma, had 26 of its 45 trials hit endpoint.
Three sponsors completed over 70 trials in 2017. The top five sponsors (Table 4) showed some movement compared to the prior three years, with Roche moving to the top of the leaderboard, Merck & Co slipping to seventh place, and AstraZeneca emerging into the top five rankings.
The more telling metric is that of the top sponsors whose trials hit their primary endpoint(s). For those sponsors with more than 70 completed trials (Table 5), the overall success rates varied between a low of 15% (Boehringer Ingelheim [BI]) to a high of 40% (Novartis).
Co-sponsor trial activity
Nearly 90% of the completed industry-sponsored trials involved only a single top 20 pharma (by pharma sales) or a single other pharma company (all other pharma [AOP]). Fewer than 4% of the trials involved two top 20 sponsors, and only 3% of trials were powered by two AOP sponsors. A total of 420 trials had some combination of co-sponsors (Table 6).
The five cancer indications with the largest numbers of trials that met primary endpoint(s)
were breast cancer (58), colorectal cancer (44), NSCLC (43), non-Hodgkin’s lymphoma (NHL; 36), and melanoma (31) (data not shown). Roche and Novartis outpaced all other sponsors, with 38 and 34 trials hitting endpoints, respectively. Besides these top two sponsors, those with 10 or more trials that attained primary endpoints included AstraZeneca, GlaxoSmithKline (GSK), Pfizer, BMS, and Celgene (Table 7). Relative success rates, however, reveal that Takeda and Celgene were the top performers last year.
AstraZeneca completed the largest numbers of trials last year, but ranked third by the metric of success. As observed for the Oncology area, rank by volume differs from rank by success rate (Table 8).
Eli Lilly topped the sponsors with 25 completed trials, followed by Johnson & Johnson (J&J) with 21, and Lundbeck (19) (Table 9). Otsuka’s 18 completed trials had the highest overall success rate – 50.0%.
Sponsors saw slightly lower success rates in 2017 compared to 2016. 2016’s leading company Novo Nordisk had a 46% success rate. By comparison, 2017’s leading company Novartis had a success rate of 40.1% (Table 5). 16 pharma sponsors had 25% or higher success rates in 2016, compared to eight in 2017. Trying to assign any reason for this decline, other than slow trial outcome reporting, would be highly speculative.
In Vivo: strategic insights for life sciences decision-maker...
<p><span>Pharma Intelligence offers a wealth of pharmaceutical industry news and strategic insight into the healthcare & biotechnology markets from around the world. Working in an interconnected global network, our 65 journalists and over 300 in-house analysts supply comprehensive analysis and reports.</span></p>
Citeline
29 Jun 2017
We've made the valuable and trustworthy content of Sitetrove and Trialtrove even better via the enhanced features of the new platform.
Scrip: industry news and insights
Mylan’s Symfi and Merck’s Zepatier gain preferred status on PBM's national preferred formulary for 2019. But more drugs are excluded from coverage – 242, up from 196 in 2018. <br />
Request a Trial
Whether you’re a small biotech start-up, research firm, generic manufacturer or a global pharmaceutical giant, you need focused, independent insight and opinion on market developments.
How can we help you?
Our team is always happy to hear from you. Please call us at:
Pharma Report Store
Have an immediate and specific information need?
Browse and buy from 1000s of analysis and research reports now:
The industry’s most trusted drug development database, Citeline's Pharmaprojects has been covering pharma R&D across global markets for 35+ years. With 68,000+ drug profiles including 15,000 drugs in active development, it’s the go-to resource for preclinical, clinical, and pipeline coverage, and lifecycle management tracking.
Trialtrove is the go-to resource for clinical trial research. Easily track your competitors' clinical R&D activity with expert insights and continually monitored trials.
Approximately 400,000 investigators in over 170 countries, all with clinical trial experience, all at your fingertips. Support your trial success and inform your principal investigator (PI) and site selection activities with Sitetrove, now on a sleek, modern interface for simpler, faster and more efficient searching.
Looking for more products Product Finder
