skip to main content
Close Icon We use cookies to improve your website experience.  To learn about our use of cookies and how you can manage your cookie settings, please see our Cookie Policy.  By continuing to use the website, you consent to our use of cookies.
Global Search Configuration

Since the ASCO 2014 abstracts were released to the public on May 14, 2014 at 5:00pm EDT, the pre-meeting buzz in the press has been mostly about immunotherapies – specifically immunotherapies targeted against the immune checkpoint inhibitors Programmed (Cell) Death 1 (PD1) and its ligand (PDL1).  The late-stage investigational PD1/PDL1 antagonists pembrolizumab/MK-3475 (Merck), nivolumab (Ono/Bristol-Myers Squibb) and  MPDL3280A (Genentech/Roche) have garnered most of the pre-ASCO press and results of trials with several other early-stage PD1/PDL1 biologics, pidilizumab (Curetech), MEDI4736 (MedImmune/AstraZeneca), MSB-0010718C (Merck KGaA),  will also be presented at ASCO.

But what other immunotherapies warrant our attention at ASCO 2014?  Promising results from immunotherapies in early-stage clinical development from a diverse array of industry and academic sponsors and/or collaborations will be presented.  Many of these therapies have already advanced into later-stage clinical trials or will be evaluated in additional trials within the next year (1).  Highlighted below are the presentations from three types of immunotherapies.

Chimeric Antigen Receptor (CAR)-Engineered T Cells

  • Results will be presented from a phase I, Memorial Sloan-Kettering (MSK)-sponsored consolidation trial after purine analog-based treatment in patients with previously untreated chronic lymphocytic leukemia for CD19-targeted CAR+ T cells.  MSK, Fred Hutchinson Cancer Center, Seattle Children’s Research Institute are collaborating with Juno Therapeutics to develop CAR immunotherapies (Juno Therapeutics).
  • Another industry-academic medical center collaboration between Novartis and the Abramson Cancer Center at the University of Pennsylvania  will discuss the clinical development of CTL019, another CAR-engineered T cell immunotherapy targeting CD19 in two presentations at ASCO on Monday June 2, 2014:  “CTL019: Genetically Engineered T Cells and Beyond: Immune Modulation Therapy in Chronic Lymphocytic Leukemia” and “CTL019: Future Directions in Immune Targeting” (CTL019 ASCO presentations).  These investigators previously presented results from two trials for CTL019 at ASH 2013.
  • A third collaboration between the Surgery Branch of the National Cancer Institute Surgery and Kite Pharma will present results about a more efficient and rapid manufacturing process for the production of CAR-engineered T cells.  Using this improved process, initiation of a Kite-sponsored clinical trial in patients with aggressive non-Hodgkin’s lymphoma is expected in early 2015.

Oncolytic Viruses

  • The CALM trial in patients with advanced melanoma for Coxsackievirus A21/Cavatak
  • A first-in-class, first-in-human trial in patients with metastatic epithelial tumors for enadenotucirev, an oncolytic  Ad11/Ad3 chimeric group B adenovirus
  • The REO13 Brain trial of wild-type reovirus (pelareorep/Reolysin) infection of patients with brain tumors following intravenous administration

Antibody-Drug Conjugates

Presentations from phase I trials include:

  • DMOT4039A in patients with unresectable pancreatic or platinum-resistant ovarian cancers
  • DNIB0600A in patients with non-small cell lung or platinum-resistant ovarian cancers
  • DSTP3086S in patients with metastatic castration-resistant prostate cancer
  • IMGN529 in patients with relapsed or refractory non-Hodgkin’s lymphoma
  • IMGN853 in patients with epithelial ovarian cancer and other folate receptor alpha positive tumors
  • MLN0264 in patients with advanced gastrointestinal cancers
  • SGN-LIV1A in patients with LIV-1 positive breast cancer

Presentations from phase I/II and phase II trials include:

  • IMMU-130 in patients with metastatic colorectal cancer
  • IMMU-132 in patients with metastatic solid tumors
  • PSMA ADC in patients with taxane-refractory metastatic castration-resistant prostate cancer

Summary table of the highlighted immunotherapies

Drug Name Disease Target Trial Phase at ASCO Industry Developer Abstract
CAR-Engineered T Cells
CD19-targeted CAR+T cells CLL CD19 I Juno 7020
CTL019 ALL, CLL CD19 I, II Novartis
PG13-CD19-H3 transduced PBL/KTE-C19 CAR B cell lymphoma or leukemia CD19 I Kite 3079
Oncolytic Viruses
Cavatak/CVA-21 melanoma II Viralytics 3031
enadenotucirev epithelial solid tumors I PsiOxus 3103
pelareorep/Reolysin brain tumors I Oncolytics 3104
Antibody-Drug Conjugates
DMOT4039A pancreatic or ovarian cancers MSLN I Genentech 2529
DNIB0600A NSCLC or ovarian cancer NaPi2b (SLC34A2) I Genentech 2504
DSTP3086S prostate cancer STEAP-1 I Genentech 5024
IMGN529 NHL CD37 I ImmunoGen 8526
IMGN853 ovarian cancer or FRα positive solid tumors FRα I ImmunoGen 5571
MLN0264 gastrointestinal tumors GCC I Millennium 3546
SGN-LIV1A breast cancer LIV-1 I Seattle Genetics TPS1143
IMMU-130 colorectal cancer CEACAM5 I/II Immunomedics 3106
IMMU-132 solid tumors Trop-2 I/II Immunomedics 3032
PSMA ADC prostate cancer PSMA II Progenics 5023

 

So look past the frenzy about the anti-PD1 and anti-PDL1 biologics at ASCO 2014 and look at the presentations about other types of immunotherapies, namely CAR-engineered T cells, oncolytic viruses and antibody-drug conjugates.  Some of these early-stage immunotherapies could steal the show at ASCO 2015

Read also

;

Next steps

Getting a demo tailored to your needs is the best way to see how our solutions will help you gain an advantage.

Request live demo now:

Our team is always happy to hear from you. Please call us at:

  • US Toll-Free  : +1 888 670 8900
  • US Toll           : +1 908 547 2200
  • UK & Europe : +44 (20) 337 73737
  • Australia        : +61 2 8705 6907
  • Japan              : +81 3 6273 4260

Or please submit your inquiry via the form so that we can provide you the best possible customer service.

Have an immediate and specific information need?

Browse and buy from 1000s of analysis and research reports now: